Mechanisms of Transport for Solutes in the Skin and Liver

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Speaker: Professor Michael Roberts (Therapeutics Research Centre, University of Queensland, Princess Alexandra Hospital)
Date: 18th November 2011

The mechanisms by which solutes move through the skin and liver involve a number of different pathways and interactions. One of our approaches to understanding these mechanisms is to regard the organ as a “black box” and to deconvolute the outflow profiles after various input functions for a range of solutes and nanoparticles. ¬†We have now moved to directly imaging the processes using multiphoton microscopy as this allows noninvasive measurement up to 200 um below the surface using spectral and fluorescent lifetime imaging.